First successful primate transplant of human pituitary tissue boosts cortisol levels

Researchers at Nagoya University in Japan have achieved a major breakthrough by successfully transplanting pituitary tissue grown from human stem cells into a primate whose pituitary gland was surgically removed. The transplanted tissue restored critical hormone signals and normalized cortisol levels, essential for regulating stress response, metabolism, and immune function. The team also demonstrated the technique's effectiveness in mice over an extended period, validating the approach's potential. This advancement could revolutionize treatment for patients with pituitary disorders, offering hope for those who have lost pituitary function due to surgery, disease, or injury.