New role of PTGES3 uncovered in liver cancer growth and immune evasion

Researchers at the Hefei Institutes of Physical Science have identified a novel function of prostaglandin E synthase 3 (PTGES3) in hepatocellular carcinoma, showing how this protein simultaneously promotes tumor growth and suppresses the immune system's ability to fight cancer. This dual mechanism explains why some liver cancers evade immune detection and progress rapidly. Understanding PTGES3's role could lead to new therapeutic strategies that target this protein to both slow tumor growth and restore immune response. This finding is particularly significant for developing combination treatments that address both the cancer cells and the body's impaired immune defense.