USC Scientists Discover Hidden Alzheimer's Trigger and Potential Treatment Breakthrough

Researchers at USC have identified promising new drug compounds that may reduce brain inflammation associated with Alzheimer's disease, particularly in individuals carrying the high-risk APOE4 gene. The compounds target cPLA2, an enzyme that appears to drive harmful neuroinflammation while maintaining essential brain functions. This discovery represents a significant advancement in understanding Alzheimer's disease mechanisms and could lead to new therapeutic approaches. The findings are especially relevant for people at genetic risk, offering potential preventive treatment options. This research opens new avenues for drug development to combat one of the most prevalent neurodegenerative diseases.