LatestInvestigational EGFR x HER3 Therapy Advances to Phase III Trial for Lung Cancer
Health

Subcutaneous Tarlatamab Shows Promise in Advanced Small Cell Lung Cancer Treatment

Subcutaneous Tarlatamab Shows Promise in Advanced Small Cell Lung Cancer Treatment
Cancer
Summary

Subcutaneous tarlatamab demonstrated a favorable safety profile and preliminary antitumor activity in patients with previously treated extensive-stage small cell lung cancer (ES-SCLC), according to phase 1b DeLLphi-308 study findings presented at the 2026 IASLC World Conference on Lung Cancer. The subcutaneous administration route offers a convenient alternative to intravenous delivery, potentially improving patient quality of life and treatment adherence. Small cell lung cancer is an aggressive malignancy with limited treatment options, making this positive preliminary data significant for patients who have exhausted standard therapies. These encouraging results support further investigation into tarlatamab's efficacy and safety profile in larger clinical trials.

Medical Xpress

Originally published on

Medical Xpress

Read full article(opens in new tab)

Fetched: September 12, 2026 at 10:00 AM

Related News

More news you might be interested in

View all
Investigational EGFR x HER3 Therapy Advances to Phase III Trial for Lung Cancer
Health
Cancer

Investigational EGFR x HER3 Therapy Advances to Phase III Trial for Lung Cancer

An investigational antibody-drug conjugate targeting EGFR and HER3 has demonstrated promising effectiveness and manageable side effects in patients with previously treated EGFR-mutated non-small cell lung cancer (NSCLC). Based on these positive results, researchers have selected the 2.5 mg/kg dose for further evaluation in the IZABRIGHT-Lung01 Phase III registrational study, a global clinical trial. This advancement represents progress in treating a subset of lung cancer patients who have developed resistance to prior therapies. The dual-targeting approach may offer improved outcomes for patients with specific genetic mutations. This milestone brings the therapy closer to potential regulatory approval and availability for eligible patients.

2 hours ago
Medical Xpress
Atezolizumab + Chemotherapy Doubles Event-Free Survival in Resectable Lung Cancer
Health
Cancer

Atezolizumab + Chemotherapy Doubles Event-Free Survival in Resectable Lung Cancer

Final results from the Phase III IMpower030 trial demonstrate that patients with resectable stage II–IIIB non-small cell lung cancer (NSCLC) receiving perioperative atezolizumab combined with platinum-based chemotherapy achieved a median event-free survival of 62.8 months, more than double the 34.9 months observed with chemotherapy alone. This immunotherapy-based approach represents a significant advancement in treating surgically resectable lung cancer, extending the time before disease progression or recurrence occurs. The combination strategy leverages atezolizumab's immune-checkpoint inhibition alongside traditional chemotherapy for enhanced treatment efficacy. These findings provide important therapeutic options for early-stage lung cancer patients and may reshape treatment protocols in oncology practices. The substantial survival benefit highlights the potential of perioperative immunotherapy in improving long-term outcomes for eligible patients with resectable disease.

2 hours ago
Medical Xpress
Local Consolidative Therapy Does Not Improve Survival in Metastatic Lung Cancer After Dual Immunotherapy
Health
Cancer

Local Consolidative Therapy Does Not Improve Survival in Metastatic Lung Cancer After Dual Immunotherapy

A major clinical trial presented at the IASLC 2026 World Conference found that adding local consolidative therapy (LCT) after treatment with nivolumab plus ipilimumab—two immunotherapy drugs—did not improve overall survival or progression-free survival in patients with metastatic non-small cell lung cancer (NSCLC). This finding applies even to patients with oligometastatic disease, a more limited form of metastatic cancer. The results suggest that for this patient population, dual immunotherapy alone may be sufficient, potentially sparing patients from additional invasive procedures. These findings could reshape treatment strategies and help oncologists make more informed decisions about which patients benefit from consolidative local treatments.

2 hours ago
Medical Xpress
Pumitamig Plus Ifinatamab Deruxtecan Shows Promise for Small Cell Lung Cancer
Health
Cancer

Pumitamig Plus Ifinatamab Deruxtecan Shows Promise for Small Cell Lung Cancer

An investigational drug combination of pumitamig and ifinatamab deruxtecan demonstrated encouraging early antitumor activity and manageable safety in patients with small cell lung cancer (SCLC), according to Phase Ib/II trial data presented at the 2026 IASLC World Conference on Lung Cancer. Small cell lung cancer is an aggressive form of lung cancer with limited treatment options, making new therapeutic approaches critical for patients. This early-stage trial represents a potential advancement in SCLC treatment, offering hope for improved outcomes in this challenging disease. The manageable safety profile is particularly important as it suggests the combination may be tolerable for patients requiring long-term therapy.

2 hours ago
Medical Xpress